Candida albicans: fundamental research on an opportunistic human pathogen
نویسندگان
چکیده
منابع مشابه
Rac1 Dynamics in the Human Opportunistic Fungal Pathogen Candida albicans
The small Rho G-protein Rac1 is highly conserved from fungi to humans, with approximately 65% overall sequence identity in Candida albicans. As observed with human Rac1, we show that C. albicans Rac1 can accumulate in the nucleus, and fluorescence recovery after photobleaching (FRAP) together with fluorescence loss in photobleaching (FLIP) studies indicate that this Rho G-protein undergoes nucl...
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Immunosuppressed patients are frequently afflicted with severe mycoses caused by opportunistic fungal pathogens. Besides being a commensal, colonizing predominantly skin and mucosal surfaces, Candida albicans is the most common human fungal pathogen. Mast cells are present in tissues prone to fungal colonization being expectedly among the first immune cells to get into contact with C. albicans....
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OBJECTIVES Polyene antifungal drugs, including amphotericin B or nystatin, target ergosterol in the fungal plasma membrane and are used to treat systemic, vaginal and oral fungal infections. In the oral cavity, the available nitrogen sources are primarily in the form of proteins, which are poor nitrogen sources. This study evaluates the effect of protein as a nitrogen source on drug susceptibil...
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ژورنال
عنوان ژورنال: FEMS Yeast Research
سال: 2009
ISSN: 1567-1356,1567-1364
DOI: 10.1111/j.1567-1364.2009.00585.x